Article
Generation of temperature-sensitive human metapneumovirus strains that provide protective immunity in hamsters.
The Journal of general virology - 1 Jul 2008
Herfst Sander, de Graaf Miranda, Schrauwen Eefje J A, Sprong Leo, Hussain Karim, van den Hoogen Bernadette G, Osterhaus Albert D M E, Fouchier Ron A M
Abstract excerpt
Human metapneumovirus (HMPV) causes acute respiratory tract illness primarily in young children, immunocompromised individuals and the elderly. Vaccines would be desirable to prevent severe illnesses in these risk groups. Here, we describe the generation and evaluation of cold-passage (cp) temperature-sensitive (ts) HMPV strains as vaccine candidates. Repeated passage of HMPV at low temperatures in Vero cells...
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