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Article

Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning.

Nature biomedical engineering - 1 Aug 2025

Metwally Ahmed A, Perelman Dalia, Park Heyjun, Wu Yue, Jha Alokkumar, Sharp Seth, Celli Alessandra, Ayhan Ekrem, Abbasi Fahim, Gloyn Anna L, McLaughlin Tracey, Snyder Michael P

Abstract excerpt

The classification of type 2 diabetes and prediabetes does not consider heterogeneity in the pathophysiology of glucose dysregulation. Here we show that prediabetes is characterized by metabolic heterogeneity, and that metabolic subphenotypes can be predicted by the shape of the glucose curve measured via a continuous glucose monitor (CGM) during standardized oral glucose-tolerance tests (OGTTs) performed in...

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Identifiers

PMID: 39715896
DOI: 10.1038/s41551-024-01311-6
PMCID: PMC12183321

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