Article
Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents.
The Journal of clinical endocrinology and metabolism - 1 May 2008
Cali' Anna M G, Bonadonna Riccardo C, Trombetta Maddalena, Weiss Ram, Caprio Sonia
Abstract excerpt
OBJECTIVE: The aim of this study was to define the metabolic abnormalities underlying the prediabetic status of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), and combined IFG/IGT in obese youth. RESEARCH DESIGN AND METHODS: We used state-of-the-art techniques (hyperinsulinemic-euglycemic and hyperglycemic clamps), applying a model of glucose-stimulated insulin secretion to...
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