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Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistant Enterococcus faecium.

Microbial genomics - 1 Jul 2026

Mills Emma G, Evans Kirsten M, Dorazio Ava J, Squires Kevin M, Sundermann Alexander J, Stellfox Madison E, Culyba Matthew J, Shields Ryan K, Van Tyne Daria

Abstract excerpt

Colonization of the gastrointestinal (GI) tract by vancomycin-resistant Enterococcus faecium (VREfm) often precedes bloodstream infection and serves as a reservoir for onward patient transmission in healthcare settings. Routine clonal isolate-based sequencing often underestimates within-patient diversity and can miss transmission involving low-abundance and co-colonizing strains. Here, we applied culture-enriched...

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Enterococcus faecium
Gastrointestinal Tract
Genetic Variation
Gram-Positive Bacterial Infections
Metagenome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vancomycin-Resistant Enterococci

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Identifiers

PMID: 42397700
DOI: 10.1099/mgen.0.001778
PMCID: PMC13331451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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