Naturally occurring mutations in envelope mediate virulence of Usutu virus.

doi:10.1128/mbio.01593-25

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Article

Naturally occurring mutations in envelope mediate virulence of Usutu virus.

mBio - 8 Oct 2025

Vogt Megan B, Marano Jeffrey M, Hanrahan William J, Hawks Seth A, Brown Anne M, Coutermarsh-Ott Sheryl, Weger-Lucarelli James, Duggal Nisha K

Abstract excerpt

Usutu virus (USUV) is a mosquito-transmitted flavivirus that is closely related to West Nile virus. Recently, USUV emerged in Europe, where it has caused multiple bird die-off events and neuroinvasive disease in humans. Previously, we showed that USUV isolates from Africa cause significantly more severe disease than European isolates in mice. Sequence analysis revealed that the most virulent isolate (Uganda 2012)...

Topics

Virulence
Mutation
Flavivirus
Animals
Mice
Viral Envelope
Viral Envelope Proteins
Flavivirus Infections
Male
Female
Phylogeny

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Identifiers

PMID: 40937854
DOI: 10.1128/mbio.01593-25
PMCID: PMC12506040

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