Development and characterization of infectious clones of two strains of Usutu virus.

doi:10.1016/j.virol.2020.12.004

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Article

Development and characterization of infectious clones of two strains of Usutu virus.

Virology - 1 Feb 2021

Bates Tyler A, Chuong Christina, Hawks Seth A, Rai Pallavi, Duggal Nisha K, Weger-Lucarelli James

Abstract excerpt

Usutu virus (USUV; genus Flavivirus; family Flaviviridae) is a mosquito-borne, positive-sense RNA virus that is currently causing significant die-offs in numerous bird species throughout Europe and has caused infections in humans. Currently, there are no molecular clones for USUV, hence, hindering studies on the pathogenesis and transmission of USUV. Here, we demonstrate the development and characterization of...

Topics

Animals
Cell Line
Cloning, Molecular
Disease Models, Animal
Flavivirus
Flavivirus Infections
Humans
Male
Mice
Mutation
Phylogeny
Viremia
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 33352463
DOI: 10.1016/j.virol.2020.12.004

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