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Article

Identification and functional characterization of regulatory variants in DPP9 associated with COVID-19 severity.

Genome medicine - 2 Jul 2026

Farah Gaëlle, Torres Magali, Henches Leo, Aschard Hugues, Ghosn Jade, Duval Xavier, Rihet Pascal, Spicuglia Salvatore, Marquet Sandrine

Abstract excerpt

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to a wide-range of clinical outcomes, which have been extensively studied through genome-wide association studies (GWAS). METHODS: Starting from lead genetic variants associated with COVID-19 infection and severity, we identified a subset of non-coding candidate variants with potential regulatory functions. We combined...

Read the complete abstract on PubMed

Topics

Humans
COVID-19
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Haplotypes

Genome-Wide Association Study

SARS-CoV-2

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 42393744
DOI: 10.1186/s13073-026-01703-0
PMCID: PMC13602522

Genes

DPP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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