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Article

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science - 1 Jul 2026

Coutinho Catarina P, Zanchetta Ferdinando, Carbonelli Michele, Battista Marco, Galzignato Alice, La Morgia Chiara, Amore Giulia, Romagnoli Martina, Brotto Luigi, Nucci Paolo, Parisi Vincenzo, Cascavilla Maria Lucia, Caporali Leonardo, Bandello Francesco, Sadun Alfredo A, Carelli Valerio, Fioresi Rita, Barboni Piero

Abstract excerpt

Purpose: To use the machine learning algorithm archetypal analysis (AA) to characterize visual field (VF) loss patterns in patients with chronic Leber hereditary optic neuropathy (LHON) and to determine whether these VF patterns differentiate for patients who recovered visual acuity (VA). Methods: For patients with molecularly confirmed LHON, we retrospectively collected 30-2 or 24-2 VFs (Humphrey VF analyzer)...

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Algorithms
Chronic Disease
Machine Learning
Optic Atrophy, Hereditary, Leber

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recovery of Function

Visual Field Tests

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Identifiers

PMID: 42390170
DOI: 10.1167/iovs.67.8.8
PMCID: PMC13348972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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