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Article

Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie - 1 Aug 2026

Takai Yasuyuki, Yamagami Akiko, Iwasa Mayumi, Inoue Kenji, Yasumoto Ryoma, Ishikawa Hitoshi, Wakakura Masato

Abstract excerpt

OBJECTIVE: To compare 5-year visual acuity trajectories in Leber hereditary optic neuropathy (LHON) by age at onset. DESIGN: A retrospective single-center cohort study. PARTICIPANTS: Fifty-seven patients (114 eyes) with genetically confirmed, bilateral-onset LHON. METHODS: Serial best-corrected visual acuity (BCVA, logMAR) over 5 years was extracted from medical records. The age at onset was grouped as ≤19,...

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Identifiers

PMID: 41833325
DOI: 10.1016/j.jcjo.2026.02.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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