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Article

Rethinking TYK2 P1104A: a flawed evolutionary trade-off in tuberculosis?

Frontiers in immunology - 1 Jan 2026

Cardona Pere-Joan

Abstract excerpt

The TYK2 P1104A variant has been cast as a textbook example of evolutionary compromise-protecting against autoimmunity whilst increasing susceptibility to tuberculosis (TB). This narrative has been invoked to explain its decline in frequency in European populations since the Bronze Age. However, accumulating evidence suggests that this widely accepted trade-off may be more complex than originally proposed. At the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42382739
DOI: 10.3389/fimmu.2026.1845279
PMCID: PMC13314518

Genes

TYK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Rethinking TYK2 P1104A: a flawed evolutionary trade-off in tuberculosis?PMID 42382739Read ↗

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