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Article

Genome-Wide Copy-Number Landscape of Germ Cell Tumors With Synchronous Conventional and "Somatic-Type" Malignancy Components.

The American journal of surgical pathology - 1 May 2026

Michalova Kvetoslava, Hruby Melissa, Baniak Nicholas, Gordetsky Jennifer B, Idrees Muhammad T, Anderson William J, Martinek Petr, Grendar Marian, Michal Michal, Ulbright Thomas M, Acosta Andres M

Abstract excerpt

So-called "somatic-type" malignancies (SMs) of germ cell tumor (GCT) origin resemble malignant neoplasms that arise from true somatic tissue. Except for enrichment in TP53 pathway alterations, the mutational profile of GCTs with SMs does not significantly differ from that of typical GCTs. Prior studies have suggested that copy number alterations (CNAs) of SMs may differ from those of conventional GCTs, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41980879
DOI: 10.1097/PAS.0000000000002515

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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