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Integrated analysis of transposon insertion sequencing and pangenome reveals core and lineage-specific essential genes in Mycobacterium avium subsp. hominissuis.

Microbial genomics - 1 Jun 2026

Sawai Kotaro, Ikai Marie, Shinohara Motoko, Nishiuchi Yukiko, Fujiyoshi So, Doi Yohei, Iwamoto Tomotada, Arikawa Kentaro, Maruyama Fumito, Minato Yusuke

Abstract excerpt

Pulmonary disease caused by non-tuberculous mycobacteria (NTM-PD) is an emerging global health concern. Among NTM, Mycobacterium avium subsp. hominissuis (MAH) is the major causative agent of NTM-PD. Similar to Mycobacterium tuberculosis, MAH exhibits lineage-specific geographical distributions and host adaptations. Here, we characterized three MAH strains from the residential bathrooms of Mycobacterium avium...

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DNA Transposable Elements
Genes, Essential
Genetic Variation
Genome, Bacterial
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

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PMID: 42348439
DOI: 10.1099/mgen.0.001753
PMCID: PMC13298725

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NTM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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