Synergistic Effects of Erythromycin and Budesonide on the Mitigation of Tracheal Stenosis Associated With Macrophage Phenotype Alteration and HDAC2 Upregulation.

Abstract excerpt

OBJECTIVE: We investigated the therapeutic effects of combined erythromycin and budesonide treatment on tracheal stenosis (TS) and the associated changes in macrophage-related markers and HDAC2 expression. METHODS: A rabbit model of TS was established by mechanical scraping of the tracheal inner wall, and the animals were then treated with erythromycin, budesonide, or their combination. Treatment effects were...

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