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Article

Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish.

Science advances - 19 Jun 2026

Mackensen Tahnee, Iñiguez Luis Pedro, Soares Mullen Thomas, Rodriguez-Marin Cristina, Kroll François, Zuccarini Giulia, Fernandez-Albert Jordi, Sancho-Vila Laia, Permanyer Jon, Bianco Isaac H, Orger Michael, Rihel Jason, Irimia Manuel

Abstract excerpt

Proper regulation of arousal maintains the balance of rest and activity and enables appropriate responses to stimuli; its disruption is a hallmark of many neurodevelopmental disorders. Although transcriptional mechanisms of arousal control are well defined, the contribution of posttranscriptional processes such as alternative splicing remains unclear. Here, we identify a critical role for the microexon splicing...

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Identifiers

PMID: 42319930
DOI: 10.1126/sciadv.ady8291
PMCID: PMC13281805

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