Article
Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".
International journal of chronic obstructive pulmonary disease - 1 Jan 2026
Li Jingli, Liu Lingjing, Tang Jixian, He Chunxiao, Pu Guimei, Sun Jian
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a life-course disorder with origins rooted in early-life insults. However, the current diagnostic reliance on the FEV1/FVC < 0.7 threshold often fails to capture the early phases of disease evolution, particularly within the pulmonary "Silent Zone." This narrative review examines small airway disease (SAD) in pre-COPD and early COPD by...
Topics
- Humans
- Pulmonary Disease, Chronic Obstructive
- Airway Remodeling
- Lung
- Predictive Value of Tests
- Prognosis
- Animals
- Risk Factors
- Phenotype