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Article

Cardiovascular-Kidney-Metabolic Multimorbidity Burden and Phenotype Differentially Influence Cardiovascular and Renal Risk in Advanced Chronic Kidney Disease.

Cardiorenal medicine - 1 Jan 2026

Marshall William R, Chinnadurai Rajkumar, Green Darren, Sinha Smeeta, Kalra Philip A

Abstract excerpt

INTRODUCTION: Chronic kidney disease (CKD) frequently coexists with cardiovascular disease (CVD), diabetes, and obesity through shared biological pathways encompassed within the American Heart Association cardiovascular-kidney-metabolic (CKM) construct. Whether adverse cardiovascular and renal outcomes in CKD are driven predominantly by cumulative multimorbidity burden or by distinct CKM disease phenotypes...

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Identifiers

PMID: 42313695
DOI: 10.1159/000553163
PMCID: PMC13446873

Genes

CKM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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