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Article

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk.

Annals of medicine - 1 Dec 2026

Wei Jianhui, Huang Peng, Chen Letao, Yang Tubao, Wang Tingting, Li Ziye, Chen Lizhang, Qin Jiabi

Abstract excerpt

BACKGROUND: Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart development, and their gene polymorphisms may contribute to CHD. Additionally, maternal periconceptional environmental exposures may influence CHD risk. Limited...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heart Defects, Congenital

Share to Homeobox Protein Nkx-2.5

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Source

Open in PubMed Open full text

Identifiers

PMID: 42311150
DOI: 10.1080/07853890.2026.2688397
PMCID: PMC13288541

Genes

GATA4
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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