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Modelling in vivo skeletal muscle ageing in vitro using three‐dimensional bioengineered constructs

8 Aug 2012

Abstract excerpt

Degeneration of skeletal muscle (SkM) with age (sarcopenia) is a major contributor to functional decline, morbidity and mortality. Methodological implications often make it difficult to embark on interventions in already frail and diseased elderly individuals. Using in vitro three-dimensional (3D) bioengineered skeletal muscle constructs that model aged phenotypes and incorporate a representative extracellular...

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PMID: 22882433
DOI: 10.1111/j.1474-9726.2012.00869.x

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