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Article

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke.

The pharmacogenomics journal - 16 Jun 2026

Deiman Birgit, Hermans Mike, de Rijk Maarten, Bras Anne, Scharnhorst Volkher

Abstract excerpt

Clopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 neurology patients who had experienced a recurrent ischemic stroke while receiving clopidogrel monotherapy. Patients were genotyped for CYP2C19, CYP2C9, CYP2B6, CYP3A4, CYP3A5, CYP1A2, ABCB1 and...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Clopidogrel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP2C9

Share to Ischemic Stroke

Share to Platelet Aggregation Inhibitors

Share to Recurrence

Share to Ticlopidine

Source

Open in PubMed Open full text

Identifiers

PMID: 42303966
DOI: 10.1038/s41397-026-00421-5
PMCID: PMC13271889

Genes

ABCB1
CYP2C19
CYP2C9
CYP1A2
CYP2B6
CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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