Article
Clustering of ABCB1 and CYP2C19 Genetic Variants Predicts Risk of Major Bleeding and Thrombotic Events in Elderly Patients with Acute Coronary Syndrome Receiving Dual Antiplatelet Therapy with Aspirin and Clopidogrel.
Drugs & aging - 1 Jul 2018
Galeazzi Roberta, Olivieri Fabiola, Spazzafumo Liana, Rose Giuseppina, Montesanto Alberto, Giovagnetti Simona, Cecchini Sara, Malatesta Gelsomina, Di Pillo Raffaele, Antonicelli Roberto
Abstract excerpt
OBJECTIVE: The clinical efficacy of clopidogrel in secondary prevention of vascular events is hampered by marked inter-patient variability in drug response, which partially depends on genetic make-up. The aim of this pilot prospective study was to evaluate 12-month cardiovascular outcomes in elderly patients with acute coronary syndrome (ACS) receiving dual antiplatelet therapy (aspirin and clopidogrel) according...
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