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Article

Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2015

Shah Rashmi R, Smith Robert L

Abstract excerpt

Phenoconversion transiently converts genotypic extensive metabolizers (EMs) into phenotypic poor metabolizers (PMs) of drugs, potentially with corresponding changes in clinical response. This phenomenon, typically resulting from coadministration of medications that inhibit certain drug metabolizing enzymes (DMEs), is especially well documented for enzymes of the cytochrome P450 family. Nonclinical evidence...

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Identifiers

PMID: 25519488
DOI: 10.1124/dmd.114.061093

Genes

NAT2

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