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Article

Mendelian Randomization and Transcriptomic Analysis Identify HE4 as a Potential Biomarker for Chronic Obstructive Pulmonary Disease.

Clinical laboratory - 1 Jun 2026

Li Mei-Xue, Zeng Zhang-Fang, Cao Zhao-Wen

Abstract excerpt

BACKGROUND: Human epididymis protein 4 (HE4), a member of the WFDC protein family, has been shown to exhibit abnormal expression in patients with chronic obstructive pulmonary disease (COPD). However, the causal relationship between HE4 and COPD, as well as the involvement of other members of the WFDC family in COPD pathogenesis, remains unclear. This study aims to investigate the potential of WFDC proteins,...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 42295288
DOI: 10.7754/Clin.Lab.2025.250536

Genes

WFDC12
WFDC2
WFDC3
WFDC10A
WFDC13
WFDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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