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Article

The diabetic wound microenvironment drives emergence and maintenance of CovRS variants in group B Streptococcus.

Infection and immunity - 14 Jul 2026

Keogh Rebecca A, Job Alyx M, Joyce Luke R, Akbari Madeline S, Nguyen Amber, Kavanaugh Jeffrey S, Horswill Alexander R, Doran Kelly S

Abstract excerpt

Diabetic wounds are often infected with microbes, which perpetuate inflammation, and stall wound healing. The bacterium Group B Streptococcus (GBS) is frequently isolated from diabetic wounds; however, little is known about how GBS adapts to survive in this niche. Previously, we found that GBS acquires stable mutations in the major two-component system CovRS during murine diabetic wound infection that result in...

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Identifiers

PMID: 42294630
DOI: 10.1128/iai.00099-26
PMCID: PMC13367057

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