Article
Primary Tumor-Associated Loss of the Y Chromosome and Clinical Outcome in Metastatic Colorectal Cancer.
Genes, chromosomes & cancer - 1 Jun 2026
Isnard Anaëlle, Decraecker Marie, Fernandez Benjamin, Smith Denis, Dubus Pierre, Dabernat Sandrine, Mansier Olivier, Amintas Samuel
Abstract excerpt
BACKGROUND: Alterations of the Y chromosome are frequent events in solid tumors, yet their biological and clinical significance remains incompletely understood. In colorectal cancer (CRC), recent studies have suggested context-dependent roles of Y-linked genes in tumor progression, while the impact of tumor-associated loss of the Y chromosome (LoY) in metastatic disease has not been clearly established. METHODS:...
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