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Exhaled Breath Condensate (EBC) analysis of circulating tumour DNA (ctDNA) using a lung cancer specific UltraSEEK oncogene panel.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2022

Ryan Daniel J, Toomey Sinead, Smyth Robert, Madden Stephen F, Workman Julie, Cummins Robert, Sheehan Katherine, Fay Joanna, Naidoo Jarushka, Breathnach Oscar S, Morris Patrick G, Grogan Liam, O'Brien Michael E, Sulaiman Imran, Hennessy Bryan T, Morgan Ross K

Abstract excerpt

INTRODUCTION: Small diagnostic tissue samples can be inadequate in testing an expanding list of validated oncogenic driver alterations and fail to reflect intratumour heterogeneity (ITGH) in lung cancer. Liquid biopsies are non-invasive and may better reflect ITGH. Most liquid biopsies are performed in the context of circulating tumour DNA (ctDNA) in plasma but Exhaled Breath Condensate (EBC) shows promise as a...

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PMID: 35526313
DOI: 10.1016/j.lungcan.2022.04.013

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