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Increased head-turning, hyperactivity and low-penetrance circling behaviour in mice lacking ZPLD1, a protein that scaffolds the cupula to the roof of the ampulla.

Hearing research - 1 Aug 2026

Montano Ilaria, Goodyear Richard J, Kenyon Emma J, Komulainen Emilia, Hacker Franziska, Knepper Marie-Isabell, Donald-Wilson Charlotte, Dernedde Jens, Kros Corné J, Bull James C, Richardson Guy P

Abstract excerpt

The study aims to understand how loss of ZPLD1 affects the behaviour of homozygous Zpld1(em1/IMPC)J mice (Zpld1-/- mice) and the structure of the cupula. Evaluation of 2-minute open-field, swim, and tail-suspension tests indicated open-field testing was optimal for detecting mutants. Mice were therefore video-recorded in an open field for 5 minutes, and DeepLabCut was trained to track the position of body parts...

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Identifiers

PMID: 42287969
DOI: 10.1016/j.heares.2026.109702

Genes

ZPLD1
OTOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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