The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma.

doi:10.1038/s41467-024-53164-x

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Article

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma.

Nature communications - 18 Oct 2024

Jiang Guozhong, Wang Zhizhong, Cheng Zhenguo, Wang Weiwei, Lu Shuangshuang, Zhang Zifang, Anene Chinedu A, Khan Faraz, Chen Yue, Bailey Emma, Xu Huisha, Dong Yunshu, Chen Peinan, Zhang Zhongxian, Gao Dongling, Wang Zhimin, Miao Jinxin, Xue Xia, Wang Pengju, Zhang Lirong, Gangeswaran Rathi, Liu Peng, Chard Dunmall Louisa S, Li Junkuo, Guo Yongjun, Dong Jianzeng, Lemoine Nicholas R, Li Wencai, Wang Jun, Wang Yaohe

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies. To address this, we perform genomic-transcriptomic characterizations and AI-aided histopathological image analysis of 120 Chinese ESCC patients. Here we show that ESCC can be categorized into...

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PMID: 39419971
DOI: 10.1038/s41467-024-53164-x
PMCID: PMC11487165

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