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Article

Genetic analysis of nucleotide-binding leucine-rich repeat (NLR) receptors in multiple sclerosis.

Immunogenetics - 1 Sept 2020

Popplewell Lisa F, Encarnacion Mary, Bernales Cecily Q, Sadovnick A Dessa, Traboulsee Anthony L, Quandt Jacqueline A, Vilariño-Güell Carles

Abstract excerpt

Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the activation and assembly of specific inflammasomes in response to danger signals. Mining exome sequencing data from 326 MS patients identified 17 rare...

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PMID: 32529290
DOI: 10.1007/s00251-020-01170-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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