Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations of genetic variants in TCF7L2, MC4R, AGT and ACE genes with cardiometabolic diseases in Black South Africans.

BMC medical genomics - 10 Jun 2026

Ngwa Ndonwi Elvis, de Buys Keren, Matshazi Don Makwakiwe, Levitt Naomi S, Lombard Carl, Davison Glenda Mary, Matsha Tandi Edith, Kengne Andre Pascal, Hemmings Sian Megan Joanna, Peer Nasheeta

Abstract excerpt

BACKGROUND: Our study investigated the association between transcription factor 7-like 2 (TCF7L2-rs7903146), angiotensin convertase enzyme (ACE-rs4646994), angiotensinogen (AGT-rs699), angiotensin II type 1 receptor (AGT1R-rs5186), fat mass and obesity-associated (FTO-rs17817499) and melanocortin 4 receptor (MC4R-, and ) single nucleotide polymorphisms (SNPs) with type 2 diabetes...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensinogen
Share to Black People
Share to Cross-Sectional Studies
Share to Hypertension
Share to Peptidyl-Dipeptidase A
Share to Receptor, Melanocortin, Type 4
Share to South Africa
Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 42271435
DOI: 10.1186/s12920-026-02395-6
PMCID: PMC13488011

Genes

MC4R
TCF7L2
ACE
AGT
FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations of genetic variants in TCF7L2, MC4R, AGT and ACE genes with cardiometabolic diseases in Black South Africans.PMID 42271435Read ↗

Association of TCF7L2 rs7903146 (C/T) Polymorphism with Type 2 Diabetes Mellitus in a Chinese Population: Clinical Characteristics and Ethnic ContextSemantic proximity Read ↗

Association between the MTNR1B, HHEX, SLC30A8, and TCF7L2 single nucleotide polymorphisms and cardiometabolic risk profile in a mixed ancestry South African population.Semantic proximity Read ↗

Association between the MTNR1B, HHEX, SLC30A8, and TCF7L2 single nucleotide polymorphisms and cardiometabolic risk profile in a mixed ancestry South African populationSemantic proximity Read ↗

Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study.Semantic proximity Read ↗

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.Semantic proximity Read ↗

Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.Semantic proximity Read ↗

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.Semantic proximity Read ↗

The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil.Semantic proximity Read ↗

Possible Role of rs7903146 Polymorphism of the Transcription Factor 7-Like 2 Gene in Genetic Predisposition to Type 2 Diabetes.Semantic proximity Read ↗

rs.11196205 Variant in the TCF7L2 Gene is Associated with an Increased Cardiovascular Risk in Individuals with Hypertension and Diabetes.Semantic proximity Read ↗

Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.Semantic proximity Read ↗

Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.