Article
Clinical Rel mutations that increase basal (p)ppGpp promote conjugal transfer of staphylococcal resistance plasmids.
Microbiology (Reading, England) - 1 Jun 2026
Deventer Ashley T, Sutherland Ava, Biernacka Daria, Johnston Paul R, Stevens Claire E, Kaczorowska Anna-Karina, Boraston Alisdair B, Hobbs Joanne K
Abstract excerpt
Conjugative transfer of plasmids represents a major route through which antibiotic resistance genes are spread. In the case of the prevalent and deadly pathogen Staphylococcus aureus, more than 90% of clinical isolates carry at least one plasmid. While plasmid-encoded mechanisms [e.g. plasmid copy number (PCN)] can influence conjugation frequency, host factors and environmental stimuli can also affect...
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