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Article

Evidence for the prognostic value of TP53 mutations in circulating tumor DNA across solid malignancies: a systematic review and meta-analysis.

BMC cancer - 8 Jun 2026

Jinyan Lan, Yibin Liang, Jiangkui Qin, Shanbo Huang, Deng Glenn, Sun Changsheng, Yongyu He, Gang Huang, Tingzhuang Yi

Abstract excerpt

BACKGROUND: The purpose of this meta-analysis study is to provide evidence for the clinical utility of TP53 mutations in circulating tumor DNA (ctDNA) as a prognostic biomarker. METHODS: We searched the PubMed, Embase, Cochrane, and Web of Science databases (last update May 2025) for studies on TP53 mutations in ctDNA or cfDNA as prognosis overall survival and in solid tumors. A total of 21 studies that met the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42260443
DOI: 10.1186/s12885-026-16265-y
PMCID: PMC13474983

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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