Article
Hypercontractile phenotype at rest in chronic coronary syndromes predicts impaired functional reserve and increased mortality.
ESC heart failure - 4 Jul 2026
Ciampi Quirino, Wang Yi, Cortigiani Lauro, Zagatina Angela, Padang Ratnasari, Kane Garvan C, Villarraga Hector R, Arruda-Olson Adelaide M, Kalinina Elena, Lowenstein Jorge, Arbucci Rosina, Lowenstein Haber Diego M, Marconi Sofia, Celutkiene Jelena, Boshchenko Alla, Ryabova Tamara, Rodriguez-Zanella Hugo, Bursi Francesca, Wierzbowska-Drabik Karina, Kasprzak Jaroslaw D, Merli Elisa, Djordjevic-Dikic Ana, Amor Miguel, Haberka Maciej, Saad Ariel, Safarova Ayten, Timofeeva Tatiana, Peteiro Vazquez Jesus, Rigo Fausto, Nikolic Aleksandra, Ostojic Miodrag, Gaibazzi Nicola, Kovacevic-Preradovic Tamara, Cerracchio Emma, Tripepi Giovanni Luigi, Yin Lixue, Villari Bruno, Pepi Mauro, Carerj Scipione, Pellikka Patricia A, Picano Eugenio
Abstract excerpt
INTRODUCTION: Transthoracic echocardiography (TTE) identifies a hypercontractile phenotype (HP) in chronic coronary syndromes (CCS), characterized by elevated resting left ventricular (LV) elastance (force = systolic blood pressure/end-systolic volume). To evaluate the prognostic significance and functional correlates of HP. METHODS: In a prospective multicentre study, 10 677 patients with CCS underwent resting...
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