Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis.

doi:10.1093/ehjci/jeaf238

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Article

Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis.

European heart journal. Cardiovascular Imaging - 30 Sept 2025

Wierzbowska-Drabik Karina, Pálinkás Eszter Dalma, D'Alfonso Maria Grazia, Mori Fabio, Del Franco Annamaria, Vazquez Jesus Peteiro, Re Federica, Tesic Milorad, Djordjevic-Dikic Ana, Pálinkás Attila, Rosa Silvia Aguiar, Losi Maria Angela, Rodriguez-Zanella Hugo, Cruz Ines, Lopes Luis Rocha, Nemes Attila, Arruda-Olson Adelaide, Wang Yi, Yin Lixue, Tripepi Giovanni L, Broncel Marlena, Bartolacelli Ylenia, Pepi Mauro, Carerj Scipione, Ciampi Quirino, Pellikka Patricia, Olivotto Iacopo, Picano Eugenio

Abstract excerpt

AIMS: Our aim was to assess the clinical and prognostic significance of the left ventricular (LV) hypercontractile phenotype (HP) in hypertrophic cardiomyopathy (HCM), which until now remains unclear. METHODS AND RESULTS: We enrolled 1533 HCM patients (age 51 ± 15 years, 965 males, 63%) with ejection fraction (EF) ≥ 50%, referred for rest transthoracic echocardiography (TTE) in 27 laboratories from 13 countries....

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PMID: 40878541
DOI: 10.1093/ehjci/jeaf238

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