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Article

Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.

European journal of pain (London, England) - 1 Jul 2026

Macian Nicolas, Dualé Christian, Delay Marine, Leray Vincent, Pereira Bruno, Renaud Yoan, Gloor Yvonne, Desmeules Jules, Pickering Gisèle

Abstract excerpt

BACKGROUND: Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway. METHODS: This study included 201 women with fibromyalgia and 40 healthy women matched on age and menopausal status. The nociceptive flexion...

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Identifiers

PMID: 42246686
DOI: 10.1002/ejp.70308
PMCID: PMC13238813

Genes

CS
TACR1
FAAH
HTR1A
IL10
MYT1L
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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