Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy-Brief Report.

doi:10.1161/ATVBAHA.126.324519

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Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026

Li Linke, Zhang Yu, Truong Buu, Yu Zhi, Gupta Rajat M, Tian Haodong, Natarajan Pradeep, Haas David M, Liu Nianjun, Honigberg Michael C

Abstract excerpt

BACKGROUND: The hypertensive disorders of pregnancy (HDPs), that is, preeclampsia and gestational hypertension, are characterized by endothelial dysfunction in pregnancy and are epidemiologically and genetically associated with risk for coronary artery disease (CAD). A recent study suggested that endothelial cell (EC)-acting CAD risk variants may identify individuals who benefit from more intensive lipid-lowering...

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PMID: 42237906
DOI: 10.1161/ATVBAHA.126.324519
PMCID: PMC13296565

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