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Article

Landscape of Chinese Lung Cancer Patients With Compound Mutations and Acquired Resistance Alterations: A Retrospective Study.

International journal of cancer - 15 Sept 2026

Huang Min, Yang Jun, Peng Pei, Wang Yongpan, Song Li, Lin Yuqin, Zhao Jiangman

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are key oncogenic drivers in non-small cell lung cancer (NSCLC). Rare and compound EGFR mutation-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we characterized compound EGFR mutations and elucidated mechanisms of acquired resistance to EGFR TKIs in Chinese NSCLC patients. Using next-generation sequencing...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42237450
DOI: 10.1002/ijc.70545
PMCID: PMC13397232

Genes

EGFR
BRAF
ERBB2
KRAS
MET
PIK3CA
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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