Article
Characterization of common and rare mutations in EGFR and associated clinicopathological features in a large population of Chinese patients with lung cancer.
Pathology, research and practice - 1 Jul 2017
Wei Bing, Ren Pengfei, Zhang Chengjuan, Wang Zhizhong, Dong Bing, Yang Ke, Zhao Jiuzhou, Tu Shichun, Ma Jie, Guo Yongjun
Abstract excerpt
Lung cancer with EGFR mutation is often associated pathological characteristics and good responses to EGFR tyrosine kinase inhibitors (TKIs). However, certain types of rare EGFR mutations have be linked to cases with poor response to EGFR TKIs. Therefore, extensive molecular screening and pathological characterization are essential for accurate diagnosis and selection of effective treatment plans. Although a...
Topics
- Adult
- Asian People
- Biomarkers, Tumor
- China
- DNA Mutational Analysis
- ErbB Receptors
- Female
- Genetic Predisposition to Disease
- Humans
- Immunohistochemistry