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Article

The Relationship Between Gas Transfer Measurements, Lung Volumes, and Spirometric Indices in Alpha-1 Antitrypsin Deficiency and Non-AATD COPD: A Systematic Review.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Alshahrani Mohammed, Alshehri Abdulrahman, Sapey Elizabeth, Stockley Robert Andrew

Abstract excerpt

Background: Alpha-1 Antitrypsin Deficiency (AATD) is associated with persistent airflow limitation with a predominant emphysema phenotype. While spirometry is the gold standard for diagnosis and staging of airflow obstruction, gas transfer is more specific for alveolar damage and may support early diagnosis. We performed a systematic review of the published evidence to support measurements of gas transfer in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42232869
DOI: 10.2147/COPD.S598023
PMCID: PMC13225003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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