Article
Small airway dysfunction across alpha-1 antitrypsin deficiency genotypes with preserved spirometry.
European journal of applied physiology - 1 Aug 2026
Marchese Alessandra, Frizzelli Annalisa, Accogli Rocco, Pisi Roberta, Bondarenko Olha, Chetta Alfredo, Aiello Marina
Abstract excerpt
PURPOSE: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that generally predisposes to pulmonary emphysema with or without chronic obstructive pulmonary disease (COPD). Despite the lack of spirometric obstruction, early Small Airways Dysfunction (SAD) may occur in AATD patients preceding lung damage. METHODS: We conducted a retrospective, single-center study on 60 AATD patients without airflow...
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