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Article

Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.

The Journal of clinical investigation - 1 Sept 2011

Kraft Michael, Cirstea Ion Cristian, Voss Anne Kathrin, Thomas Tim, Goehring Ina, Sheikh Bilal N, Gordon Lavinia, Scott Hamish, Smyth Gordon K, Ahmadian Mohammad Reza, Trautmann Udo, Zenker Martin, Tartaglia Marco, Ekici Arif, Reis André, Dörr Helmuth-Guenther, Rauch Anita, Thiel Christian Thomas

Abstract excerpt

Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important targets of genetic diseases. However, surprisingly little is known about the re...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21804188
DOI: 10.1172/JCI43428
PMCID: PMC3163944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21804188-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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