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Article

The causal association between sleep traits and osteoarthritis traits: evidence from bidirectional mendelian randomization.

Human molecular genetics - 26 May 2026

Chen Shibo, Southam Lorraine, Arruda Ana Luiza, Zeggini Eleftheria

Abstract excerpt

Sleep disorder is associated with risk of osteoarthritis, yet their causal association has not been fully understood. This study aims to evaluate the causal association between sleep traits and osteoarthritis, by performing two sample Mendelian randomization (MR) leveraging the currently largest genome-wide association study (GWAS) summary statistics for sleep traits and osteoarthritis traits. We demonstrate that...

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Identifiers

PMID: 42224456
DOI: 10.1093/hmg/ddag043
PMCID: PMC13225258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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