Article
Effects of fluoroquinolone antibiotics on extracellular matrix-related phenotypes in tendon cells.
Scientific reports - 30 May 2026
Anand Akshay, Sakai Keiko, Dickens David, Tsuzuki Sadatoshi, Minamiguchi Sachiko, Asai Naoya, Kazaili Ahmed, Akhtar Riaz, Pirmohamed Munir, Sakai Takao
Abstract excerpt
Fluoroquinolones (FQ) are amongst the most widely prescribed antibiotics used to treat a wide range of infections because of their excellent gastrointestinal absorption, superior tissue penetration and broad-spectrum activity. However, FQs can cause rare, though serious, collagen-associated adverse reactions, including tendinopathy, and there is still no clear framework for understanding the phenotypes relating...
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