Article
No Evidence of a Genetic Causal Relationship between Ankylosing Spondylitis and Gut Microbiota: A Two-Sample Mendelian Randomization Study.
Nutrients - 20 Feb 2023
Yang Mingyi, Wan Xianjie, Zheng Haishi, Xu Ke, Xie Jiale, Yu Hui, Wang Jiachen, Xu Peng
Abstract excerpt
Objective: Ankylosing spondylitis (AS) is associated with a variety of gut microbiotas. We aim to analyze the causal relationship between the two at the genetic level. Methods: Mendelian randomization (MR) is a type of instrumental variables (IVs) analysis; MR follows the Mendelian genetic rule of "parental alleles are randomly assigned to offspring" and takes genetic variation as IVs to infer the causal...
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