Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Analytical Framework for Phenotypic Selection of Fitness-Conferring Genes.

Bulletin of mathematical biology - 29 May 2026

Sturrock Marc, Sturrock Anna

Abstract excerpt

Phenotypic selection can cause the transient, selective upregulation of fitness-conferring genes in isogenic cell populations under stress, producing selective enrichment of the fitness gene relative to a neutral reference gene. While computational models have shown that such enrichment requires noisy gene expression and a cellular memory linking growth rate to gene expression (Ciechonska et al. 2022), the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Feedback, Physiological
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mathematical Concepts

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Selection, Genetic

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 42213252
DOI: 10.1007/s11538-026-01670-y
PMCID: PMC13221348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Analytical Framework for Phenotypic Selection of Fitness-Conferring Genes.PMID 42213252Read ↗

Effect of phenotypic selection on stochastic gene expression.Semantic proximity Read ↗

Inferring fitness landscapes and selection on phenotypic states from single-cell genealogical data.Semantic proximity Read ↗

Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations.Semantic proximity Read ↗

Effect and evolution of gene expression noise on the fitness landscape.Semantic proximity Read ↗

Nonlinear fitness landscape of a molecular pathway.Semantic proximity Read ↗

Phenotypic switching in gene regulatory networks.Semantic proximity Read ↗

Relevance of phenotypic noise to adaptation and evolution.Semantic proximity Read ↗

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancerSemantic proximity Read ↗

A unified framework for measuring selection on cellular lineages and traits.Semantic proximity Read ↗

Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories.Semantic proximity Read ↗

Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.Semantic proximity Read ↗

Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.