Article
Effect and evolution of gene expression noise on the fitness landscape.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Aug 2015
Charlebois Daniel A
Abstract excerpt
Gene expression is a stochastic process that affects cellular and population fitness. Noise in gene expression can enhance fitness by increasing cell to cell variability as well as the time cells spend in favorable expression states. Using a stochastic model of gene expression together with a fitness function that incorporates the costs and benefits of gene expression in a stressful environment, we show that the...
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