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Ancestral and divergent roles of the Marchantia polymorpha ATAXIA TELANGIECTASIA AND RAD3-RELATED kinase in maintaining genome integrity and clonal fitness.

The Plant cell - 2 Jun 2026

Li Qian-Qian, Li Huiying, De Moor Jolien, Sbrocca Irene, Xiang Yanli, Yang Shao-Li, Jiang Zhi-Yi, He Lin, Wang Jia-Yang, Herbst Josephine, van de Cotte Brigitte, De Smet Ive, Cimini Sara, De Veylder Lieven

Abstract excerpt

The eukaryotic ATAXIA TELANGIECTASIA AND RAD3-RELATED (ATR) kinase is essential for ensuring genomic integrity under conditions that cause replication defects. It triggers a transient cell cycle arrest and DNA repair by activating the DNA damage response pathway. While ATR kinases appear to be functionally conserved, species-specific phenotypes can be observed across the plant kingdom. To investigate the...

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PMID: 42203494
DOI: 10.1093/plcell/koag151

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ATR

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Ancestral and divergent roles of the Marchantia polymorpha ATAXIA TELANGIECTASIA AND RAD3-RELATED kinase in maintaining genome integrity and clonal fitness.PMID 42203494Read ↗

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