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Article

DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Waterworth Wanda M, Footitt Steven, Bray Clifford M, Finch-Savage William E, West Christopher E

Abstract excerpt

Genome integrity is crucial for cellular survival and the faithful transmission of genetic information. The eukaryotic cellular response to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR). Here we identify important physiological roles for these sensor kinases in control of seed germination. We demonstrate that double-strand breaks...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Desiccation

Share to DNA Breaks, Double-Stranded

Share to DNA, Plant

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Source

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Identifiers

PMID: 27503884
DOI: 10.1073/pnas.1608829113
PMCID: PMC5003248

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.PMID 27503884Read ↗

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ATM directs DNA damage responses and proteostasis via genetically separable pathways.Semantic proximity Read ↗

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The nuclear protein Poly(ADP-ribose) polymerase 3 (AtPARP3) is required for seed storability in Arabidopsis thaliana.Semantic proximity Read ↗

The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5.Semantic proximity Read ↗

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AtATM is essential for meiosis and the somatic response to DNA damage in plants.Semantic proximity Read ↗

Ancestral and divergent roles of the Marchantia polymorpha ATAXIA TELANGIECTASIA AND RAD3-RELATED kinase in maintaining genome integrity and clonal fitness.Semantic proximity Read ↗

AtSERK1 and BAK1/AtSERK3 positively regulate seed germination in response to saline condition in Arabidopsis.Semantic proximity Read ↗

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