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Article

Prognostic Score for Myelodysplastic Syndromes Based on Molecular Evolution.

NEJM evidence - 1 Jun 2026

Civettini Ivan, Malighetti Federica, Villa Matteo, Crippa Valentina, Aroldi Andrea, Cavalca Fabrizio, Graudenzi Alex, Lanino Luca, Maggioni Giulia, Haferlach Torsten, Fenaux Pierre, Platzbecker Uwe, Díez-Campelo María, Borin Lorenza Maria, Fumagalli Monica, Zappaterra Arianna, Manghisi Beatrice, Al Ali Najla H, Sallman David A, Padron Eric, Xie Zhuoer, Chan Onyee, Zeidan Amer M, Mologni Luca, Piazza Rocco, Komrokji Rami S, Della Porta Matteo Giovanni, Gambacorti-Passerini Carlo, Ramazzotti Daniele

Abstract excerpt

BACKGROUND: Myelodysplastic syndromes are clonal hematopoietic stem cell disorders characterized by multistep molecular evolution and a variable risk of leukemic transformation. Given this prognostic heterogeneity, accurate risk stratification is essential for clinical decision-making. We developed ProgEvo, a proprietary framework that infers molecular evolutionary trajectories and integrates them with clinical...

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Source

Identifiers

PMID: 42188988
DOI: 10.1056/EVIDoa2500124

Genes

NRAS
ATRX
KRAS
MCC
ASXL1
JAK2
RUNX1
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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