Article
Genetic ancestry-concordant ceramide metabolism and response to androgen receptor pathway inhibition in metastatic castration-resistant prostate cancer.
Cancer - 1 Jun 2026
Piwarski Sean A, Howard Lauren E, Paul Morgan A, Bachelder Nick, LaCroix Bonnie, Clayton Angela, Allen Donna, Kephart Julie, Armstrong Andrew J, Patierno Steven R, George Daniel J, Hyslop Terry, Freedman Jennifer A
Abstract excerpt
BACKGROUND: The authors observed differences in response between Black and White patients with metastatic castration-resistant prostate cancer (mCRPC) who were treated prospectively with androgen receptor pathway inhibition (ARPI) in the Abi Race and PANTHER studies. In addition, genetic ancestry-related single nucleotide variants in ceramide metabolism genes were associated with the time to prostate-specific...
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