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Article

Effect of sequential laboratory passaging on virulence factors traits and antifungal susceptibility variation in Candida albicans clinical isolates.

BMC microbiology - 25 May 2026

Nouraei Hasti, Yousefi Zahra, Zareshahrabadi Zahra, Amirzadeh Neda, Rajabi Seyedeh Zahra, Pakshir Keyvan

Abstract excerpt

BACKGROUND: The virulence of Candida albicans is associated with phenotypic plasticity and hydrolytic enzyme production. However, routine laboratory subculturing represents a large and understudied variable that has the potential to diminish research reproducibility and diagnostic accuracy. In this study, we investigated the effect of serial passages on key virulence factors and antifungal susceptibility...

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Identifiers

PMID: 42185756
DOI: 10.1186/s12866-026-05214-1
PMCID: PMC13386734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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